Comedian George Lopez has a Genetically inherited Kidney

The Comedian George Lopez has had a kidney transplant surgery via a received donated kidney from his wife at a Los Angeles centre.

 

Comedian George Lopez has a Genetically inherited Kidney Disease Requiring a Kidney Transplant

 

The Comedian George Lopez has had a kidney transplant surgery via a received donated kidney from his wife at a Los Angeles centre. His spokesperson inform that Lopez has a genetically inherited disease that is complicated by kidney failure. Polycystic kidney disease is the most commonly reported genetic disease that may be ended by kidney failure. This disease is characterizing by the growth of many fluid-filled cyst (s) inside the kidney tissues that are gradually replacing the functioning tissues, so that by time, there may be insufficient functioning kidney tissues to keep a normal kidney function and kidney failure will eventually ensue.

 

 

Almost one ½ of ptns with the major type of polycystic kidney disease may progress to ESRD, requiring DX or a new kidney allograft that makes it the 4^th leading cause of ESRD. Considering the National Institute of DM & Digestive & Kidney Disease (NIDDKD) almost 500,000 Americans are suffering from polycystic kidney disease. About 90% of this number are ADPKD (autosomal dominant polycystic kidney disease) where Sms usually presented between 30^th & 40^th of ages. On the other hand, the Autosomal recessive type of polycystic kidney disease is a rarer type with Sms starting during pregnancy. The most commonly observed Sms of ADPKD are pain per back & loins (between ribs & the hips), and headache. A dull aching pain can be developed temporarily or persistently, mild or intense. Additional Sms may include:

 

• HT
• UTI
• Hematuria
• Diverticulosis
• Hepatic & pancreatic cysts
• Valvular heart diseases.
• Renal calculi (usually urates)
• Vascular aneurysmal disease.

George Lopez

 

The ADPKD diagnosis is usually established by the finding of multiple kidney cysts on radiological testing i.e., U/S, MRI or CT. To limit the false negative & false positive finding related to multiple simple cysts, the diagnostic criteria that are used to establish a Dgx are typically categorized according to the age as follows:

• Ptns < 30 ys of age, at least 2 cysts (unilateral or bilateral).
• Ptns at 30-59, at least 2 cysts in each kidney.
• Ptns over age 60, 4 or more cysts in each kidney.

 

 

Dgx is augmented by a FH (family history) of ADPKD + finding of cysts in other organs. Genetic testing can document mutations in the PKD1 & PKD2 genes. Despite this test can identify the finding of the ADPKD mutations prior to cystic development, its significance is currently showed 2 limitations:

o   First: Lack of predicting ability regarding disease onset or its severity &

o   Second: Absence of definite cure as a prophylactic measure preventing disease onset.

However, disease progress can be declined by better BP control. With disease progress surgical removal of fluid from cysts may relieve back/flanks pains, but this relief is transient and cannot decline disease progress. As ptns with ADPKD show a higher risk of aneurysmal formation, ptns should consult his physician regarding using a counter headache remedy. ADPKD ptns may show a higher rate for UTI that if left untreated, may ascend to the cysts inside the kidneys, thus UTIs necessitate proper AB therapy. 

George Lopez