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Vaccines preventing intense acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be considered the mostly promising technique to contro



Coronavirus disease 2019 (COVID-19): Vaccines to prevent SARS-CoV-2 infection

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Vaccines preventing intense acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be considered the mostly promising technique to control this pandemic. The evolution of SARS-CoV-2 vaccine is proceeding in an outstanding pacing.  

Non-human primary trials & epidemiological human reports suggest that SARS-CoV-2 infection may result in the evolution of functionally neutralizing AB that can be protecting from subsequent infection. These data are supporting the concept that a given vaccine with neutralizing AB could probably protecting against the next infection. Neutralizing AB + Th1-polarizing cellular immune response are crucial  in decreasing the risk of vaccine-enhanced infection. The essential Ag target for SARS-CoV-2 vaccine is the large surface spiking proteins that bind to the ACE2 receptor on host cell inducing a membrane fusionSARS-CoV-2 vaccine evolution was via multiple and variable platforms. Some of which were traditional, e.g., inactivated or live attenuated viral platform, others were newer platforms, e.g.,  recombinant proteins vector vaccines, moreover, some have never been implemented in a licensed vaccine, e.g.,  RNA & DNA vaccines.  


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Many vaccine candidates have shown immunogenicity with no considerable safety matters in the early-phases of human studies. 2 mRNA vaccine candidates have also been shown to provide about 95 % vaccine efficacy in the prevention of lab-confirmed Sms coronavirus infection 2019 (COVID-19). Many vaccines are now available in the world. In the US, added to the traditional approaches for licensing a vaccine, the FDA can make vaccines meeting particular safety & efficacy criteria available faster via the emergency use authorization (EUA). The COVID-19 mRNA vaccine BNT162b2 has been favored the EUA for prophylaxis against COVID-19 in subjects of >16 ys of age. Regarding vaccines under EUA umbrella, physicians must inform candidate recipients that the vaccine is NOT licensed yet, explaining why it is not licensed, and types of data the FDA is waiting for prior to giving a complete license; a signed consent document is not currently warranted.  



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Distribution of a limited vaccination supplies that was initially available should be proceeded with complete equitability and efficacy. Expertized organizations are currently providing a guidance for vaccination maximizing the personal and society benefits of commencing vaccination.   Employees in major industries and risky subjects for serious infection should hav the first priorities. For subjects with eligibility for vaccination considering the regional priorities, vaccination with COVID-19 mRNA vaccine is currently recommended. BNT162b2 (Pfizer-BioNTech COVID-19 Vaccine) is usually given by 2 IM injections given 3 wks apart; mRNA-1273 (Moderna COVID-19 Vaccine) is administered by 2 IM injections with 4 weeks apart.  


Variable vaccines are available worldwide. Some of them have been thoroughly investigated, whilst others have no evident data. With local absence of mRNA vaccine, the ChAdOx1 nCoV-19/AZD1222 vaccine is an appropriate alternate. Other generally available vaccines may also be appropriate alternates, despite additional peer-reviewed information are currently warranted. After availability & widespread uptake of SARS-CoV-2 vaccination, efficacy considerations should be revised, including the protective period and the potential requirement of booster doses, efficacy in sub-populations not conducted in the study, as well as its reflection on community transmission. Safety considerations that were not previously clear may also superadded. In the US, existing active & passively monitored systems are currently triggered for assessment of the SARS-CoV-2 vaccine general safety.