Lupus pernio (LP) is a violaceous or erythematous indurated papules, plaques, or nodules that’re mainly observed on the nose, cheeks, chin, & ears.
Extra-pulmonary manifestations of sarcoidosis (Sc)
Lupus pernio: Red-to-purple indurated plaques & nodules affecting the nose & cheeks.
Lupus pernio (LP) is a violaceous or erythematous indurated papules, plaques, or nodules that’re mainly observed on the nose, cheeks, chin, & ears. LP is associated with a higher risk for nasal involvement with Sc
1) Sc can affect all systemic organs. The most commonly affected site of
extra-pulmonary disease include the skin,
eyes, reticuloendothelial
system, musculoskeletal system, exocrine glands, heart, kidney, and CNS. Extra-pulmonary
affection vary according to sex, age at presentation, & ethnicity.
2) Cutaneous affection is seen in about 25 % of Sc ptns and
usually an early finding. Sc can cause anterior,
intermediate, & posterior uveitis,
in addition to retinal peri-phlebitis.
3) Extraocular affection may involve the lacrimal gland,
conjunctiva, & ocular muscles.
Ptns with suspected Sc should commence
ophthalmologic testing.
4) Sc can involve the larynx, pharynx, nares,
and/or sinuses and should be
suspected in all ptns with systemic Sc and upper
respiratory tract Sms.
5) Cardiac Sc may be benign, incidentally observed or a life-threatening
state leading to sudden death. The spectrum of Sc cardiac affection
may include heart block & arrhythmias
(due to involved conducting system), HF, valvular malfunction, & pericardial disease. Initial asessment should include an ECG.
6) Acute polyarthritis due to Sc typically induce
symmetric affection of the ankle joint,
but can affect other joints. A characteristic criterion is extension of the swelling to involve the soft tissue around
the joint, leading to peri-arthritis rather than a true
arthritis.
7) Neurologic affection seen in about 5 % of ptns with Sc
and could be the presenting feature. Clinical
syndromes may include cranial mononeuropathy,
neuroendocrine malfunction, a focal/multifocal encephalopathy, myelopathy, hydrocephalus,
aseptic meningitis, peripheral neuropathy.
8) Löfgren syndrome (LS) is a combination of erythema nodosum (EN) +
hilar adenopathy + migratory
poly-arthralgia + pyrexia. The presence of all features of LS
has almost 95 % specificity
to diagnose Sc. However, EN with no added features has a wide DD. Painless swelling affecting
salivary &
parotid glands seen in 5 % of ptns with Sc.
9) Endocrine involvement of Sc include hypothalamic affection
(basilar granulomatous meningitis)
with infiltrated thyroid gland. Sc may also occasionally affect the uterus, ovaries, & testes.
Alterations related to Ca+ metabolism are the most commonly seen
renal & electrolyte changes observed among Sc ptns. Abnormal Ca+ metabolism can lead to nephrocalcinosis
& nephrolithiasis. Other
relatively common renal complications may include interstitial
nephritis & MN. Clinically determined GIT lesions
seen in < 1
% of ptns with Sc. Affected areas may
include the esophagus, appendix, colon,
rectum, liver, pancreas, & rarely small
intestine. Routine monitoring of Sc may
include evaluation for the types of extra-pulmonary Sc that can induce organ or life-threatening disease,
despite the validity of this monitoring has not been totally formalized.
RENAL & ELECTROLYTE ALTERATIONS OF SARCOIDOSIS (Sc)
Ptns with Sc
having neither renal Sms nor established renal Sc,
consensus guideline of ATS (American Thoracic
Society) suggests
basal SCr measuring to evaluate renal Sc. Ptns with Sc
with no Sms or Sns of hypercalcemia, guidelines
from the ATS recommend baseline s. Ca+ value for screening abnormal Ca+ metabolism. Disorders related to Ca+ metabolism are the most common renal & electrolyte alterations seen among Sc
ptns. Defects in Ca+ metabolism
is related to extrarenal production of calcitriol by activated
macrophages. Manifestations of metabolic Ca+ alterations include higher intestinal Ca+ absorption, hypercalciuria (seen in 50
% of ptns), hypercalcemia (seen in 10-20
%), nephrocalcinosis + nephrolithiasis.
Untreated, deposited kidney Ca+
>> CRF & ESRD.
Sc interstitial nephritis
is more commonly observed on
the initial presentation of Sc,
rather than ptns with chronic disease. Dgx is suggested by the combination of
high Cr level + bland urine sediment
in a ptn with known or likely Sc.
Kidney biopsy
reveals normal glomeruli, mononuclear
cell infiltration, & non-caseating granulomas. Despite the renal granulomatous infiltration is not commonly
seen, it’s rarely a single cause of kidney dysfunction.
Other sequelae of Sc include MN, a proliferative
or crescentic
GN, FGS, polyuria (owing
to nephrogenic and/or central DI), HT,
& some tubular deficits.
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