Loading ...

Followers

RENAL SARCODOSIS

RENAL SARCODOSIS

 

RENAL SARCODOSIS

 


renal sarcoidosis renal sarcoidosis treatment renal sarcoidosis approach to diagnosis and management renal sarcoidosis prognosis renal sarcoidosis ultrasound renal sarcoidosis symptoms can sarcoidosis be diagnosed by biopsy what is sarcoidosis of the kidney renal calculus sarcoidosis sarcoidosis and chronic renal failure sarcoidosis renal side effects sarcoidosis renal failure treatment for renal sarcoidosis sarcoidosis and acute renal failure sarcoidosis renal manifestations what is the treatment of sarcoidosis


Renal involvement that can be defined by either renal histologic alteration or a deterioration in kidney function, occurs in 35-50 % of ptns with sarcoidosis, though is commonly undetected. Primary renal manifestations include nephrolithiasis & nephrocalcinosis + acute interstitial nephritis with or without granuloma formation. The classic renal lesion is non-caseating granulomatous interstitial nephritis, but this lesion per se rarely induces a clinically significant renal disease. Hypercalciuria & hypercalcemia are mostly inducing the clinically significant renal disease. Glomerular disease, obstructive uropathy, and ESKD can also be seen but are   not common.  

 

renal sarcoidosis renal sarcoidosis treatment renal sarcoidosis approach to diagnosis and management renal sarcoidosis prognosis renal sarcoidosis ultrasound renal sarcoidosis symptoms can sarcoidosis be diagnosed by biopsy what is sarcoidosis of the kidney renal calculus sarcoidosis sarcoidosis and chronic renal failure sarcoidosis renal side effects sarcoidosis renal failure treatment for renal sarcoidosis sarcoidosis and acute renal failure sarcoidosis renal manifestations what is the treatment of sarcoidosis

Nephrocalcinosis & nephrolithiasis are the result of hypercalcemia and/or hypercalciuria induced by hyperabsorption of ingested Ca owing to increased production of calcitriol by the activated mononuclear cells. Stones are consisted primarily of Ca+ oxalate, but can be mixed with Ca+ phosphate. Ptns may show polyuria + eGFR decline due to hypercalcemia-induced pre-glomerular arteriole vasoconstriction. Steroids (anti-inflammatory effect > diminish calcitriol synthesis), chloroquine, hydroxychloroquine, & ketoconazole can improve Ca+ metabolism in sarcoid ptns. Ptns with sarcoidosis interstitial nephritis present with an high SCr that’s detected on routine lab profiles in the initial evaluation for sarcoid disease. Ptns mostly have clear evidence of diffuse active sarcoidosis elsewhere in his body. Normal urinalysis is a common finding or with only sterile pyuria or mild proteinuria.

 

renal sarcoidosis renal sarcoidosis treatment renal sarcoidosis approach to diagnosis and management renal sarcoidosis prognosis renal sarcoidosis ultrasound renal sarcoidosis symptoms can sarcoidosis be diagnosed by biopsy what is sarcoidosis of the kidney renal calculus sarcoidosis sarcoidosis and chronic renal failure sarcoidosis renal side effects sarcoidosis renal failure treatment for renal sarcoidosis sarcoidosis and acute renal failure sarcoidosis renal manifestations what is the treatment of sarcoidosis

There’s no single diagnostic test for sarcoidosis. Dgx of sarcoidosis-induced interstitial nephritis is usually given via a renal biopsy that shows an interstitial mononuclear infiltrate, non-caseating granuloma, tubular injury, and, with more disease chronicity, interstitial fibrosis. These findings may suggest, but not diagnostic of sarcoidosis. Considering interstitial nephritis here must rely mainly upon the exclusion of other etiologies and upon the declaration of extrarenal manifestations of sarcoid disease to confirm the diagnosis. Sometimes, ptns with renal sarcoidosis have no extrarenal manifestations upon presentation. So, all ptns with granulomatous interstitial nephritis on kidney biopsy should perform a chest radiograph, pulmonary function testing, and, if these’re non-diagnostic, a high-resolution chest CT to evaluate for pulmonary sarcoidosis.  

Steroids have been reported to be an effective ttt for ptns with sarcoid interstitial nephritis, despite the recovery may be incomplete due to longstanding disease with irreversible renal damage. All ptns with decreased eGFR related to biopsy-proven sarcoidosis interstitial nephritis, a trial of oral prednisone is suggested. Optimal dose is not certain. A given regimen is prednisone 1 mg/kg/d for 6-12 weeks, with a slow tapering thereafter to maintain the dose of 10-20 mg for an additional 6-9 months.  Ptns may present with GN, despite the relationship to sarcoidosis has not been proven. As in other forms of sarcoid nephropathy, the steroids can improve kidney function. Ureteral obstruction as a result of:

1)    Nephrolithiasis,

2)    Retroperitoneal fibrosis,

3)    Retroperitoneal lymph node affection, &

4)    Direct ureteral involvement by sarcoid.

Obstructive uropathy due to retroperitoneal affection may be responsive to steroid therapy, but invasive urologic decompression or HDX may be required prior to a clinically significant response. ESKD with the need of RRT is uncommon, despite many ptns may show a decreased eGFR.  

 

COMMENTS

Name

Hemodialysis,21,My Publications,2,Peritoneal dialysis,14,Prevention of renal failure,61,Renal face,43,Renal Transplantation,49,TOP RECENT,37,
ltr
item
fedo: RENAL SARCODOSIS
RENAL SARCODOSIS
RENAL SARCODOSIS
https://lh3.googleusercontent.com/-iQfeQCIbaoY/X8NFwx4UkfI/AAAAAAAAAgc/Ql2TYdO_YU8BNubcPXQj_4Y1bVipha10gCLcBGAsYHQ/w309-h320/image.png
https://lh3.googleusercontent.com/-iQfeQCIbaoY/X8NFwx4UkfI/AAAAAAAAAgc/Ql2TYdO_YU8BNubcPXQj_4Y1bVipha10gCLcBGAsYHQ/s72-w309-c-h320/image.png
fedo
https://www.fedokidney.com/2020/11/renal-sarcodosis.html
https://www.fedokidney.com/
https://www.fedokidney.com/
https://www.fedokidney.com/2020/11/renal-sarcodosis.html
true
8610857019469578230
UTF-8
Loaded All Posts Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share to a social network STEP 2: Click the link on your social network Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy Table of Content