DIFFERENTIAL DIAGNOSIS OF INFECTION FOLLOWING RENAL TRANSPLANTATION Infecti...
DIFFERENTIAL DIAGNOSIS OF INFECTION FOLLOWING RENAL TRANSPLANTATION
Infectious
episodes are the leading event of morbidity and mortality during the early post-transplant
stage, almost > 80 % of TRs (transplant recipients) may experience at least one infectious
episode through the 1st year. Infection as well as graft malfunction
induced by rejection are both closely related to the magnitude of the immunosuppressive
burden.
The
main risk factor for post-transplant infectious episodes is highly related to the
magnitude of overall immunosuppression administrated in the induction therapy,
maintenance immunosuppression as well as that given for the management of acute
rejection and particular immunosuppressive agent per se. Moreover, the behavior
of the post-transplant opportunistic infection may be
altered via the traditional use of the prophylactic antimicrobials given for
Pneumocystis carinii (P. jirovecii) and CMV (cytomegalovirus).
These alterations have been changed due to the advent of the newly presented
clinical syndromes (e.g. polyoma allograft nephropathy) and owing to infection caused
by resistant organisms to antimicrobial management.
